With 36 wins from the last 73 meetings between the sides, Southampton boast a superior record in the history of this fixture.
Swansea City have picked up 21 wins in that time, while the spoils have been shared on 16 occasions.
Southampton have won their last three games against the Swans, scoring seven goals and conceding three since a goalless draw in August 2017.
Swansea City are unbeaten in four of their last five matches, picking up two wins and two draws since the start of December.
The Saints have won their last five games
at the St. Mary's Stadium, stretching back to a 1-1 draw against Rotherham
United on October 7.
While Swansea will look to pick up where they left off in midweek, they face the stern challenge of taking on a Southampton side who are unbeaten in 15 consecutive matches. Martin’s men have been near-impenetrable at home over the last three months, tipping them to claim all three points once again.